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雜志名稱：Advanced Science
影響因子：15.1
文章題目：Engineering Photothermal Catalytic CO2 Nanoreactor for Osteomyelitis Treatment by In Situ CO Generation
DOI：http://doi.org/10.1002/advs.202402256
第一作者：Fan Zhuang，Luxia Jing，Huijing Xiang，Cuixian Li，Beilei Lu，Lixia Yan，Jingjing Wang，Yu Chen，Beijian Huang
作者單位：復(fù)旦大學(xué)附屬中山醫(yī)院；上海大學(xué)生命科學(xué)學(xué)院；溫州市實(shí)驗(yàn)室上海大學(xué)溫州研究所；上海材料研究所
引用YOBIBIO產(chǎn)品：U96-1511E Mouse IL-6 ELISA Kit；U96-3112E Mouse TNF-α ELISA kit；U96-1494E Mouse IL-1β ELISA Kit
文章摘要：
Photocatalytic carbon dioxide (CO2) reduction is an effective method for in vivo carbon monoxide (CO) generation for antibacterial use. However, the available strategies mainly focus on utilizing visible-light-responsive photocatalysts to achieve CO generation. The limited penetration capability of visible light hinders CO generation in deep-seated tissues. Herein, a photothermal CO2 catalyst (abbreviated as NNBCs) to achieve an efficient hyperthermic effect and in situ CO generation is rationally developed, to simultaneously suppress bacterial proliferation and relieve inflammatory responses. The NNBCs are modified with a special polyethylene glycol and further embellished by bicarbonate (BC) decoration via ferric ion-mediated coordination. Upon exposure to 1064 nm laser irradiation, the NNBCs facilitated efficient photothermal conversion and in situ CO generation through photothermal CO2 catalysis. Specifically, the photothermal effect accelerated the decomposition of BC to produce CO2 for photothermal catalytic CO production. Benefiting from the hyperthermic effect and in situ CO production, in vivo assessments using an osteomyelitis model confirmed that NNBCs can simultaneously inhibit bacterial proliferation and attenuate the photothermal effect-associated pro-inflammatory response. This study represents the first attempt to develop high-performance photothermal CO2 nanocatalysts to achieve in situ CO generation for the concurrent inhibition of bacterial growth and attenuation of inflammatory responses.
光催化二氧化碳(CO2)還原是一種有效的抑菌用體內(nèi)一氧化碳(CO)生成方法。然而，現(xiàn)有的策略主要集中在利用可見(jiàn)光響應(yīng)的光催化劑來(lái)實(shí)現(xiàn)CO的生成。可見(jiàn)光有限的穿透能力阻礙了深層組織中CO的產(chǎn)生。本研究合理開(kāi)發(fā)一種光熱CO2催化劑(簡(jiǎn)稱NNBCs)，實(shí)現(xiàn)高效的高溫效應(yīng)和原位CO生成，同時(shí)抑制細(xì)菌增殖和緩解炎癥反應(yīng)。nnbc用一種特殊的聚乙二醇修飾，并通過(guò)鐵離子介導(dǎo)的配位用碳酸氫鹽(BC)修飾。在1064 nm激光照射下，NNBCs通過(guò)光熱CO2催化促進(jìn)了高效的光熱轉(zhuǎn)化和原位CO生成。具體來(lái)說(shuō)，光熱效應(yīng)加速了BC分解生成CO2，用于光熱催化CO生產(chǎn)。得益于高溫效應(yīng)和原位CO生成，使用骨髓炎模型的體內(nèi)評(píng)估證實(shí)，nnbc可以同時(shí)抑制細(xì)菌增殖并減弱光熱效應(yīng)相關(guān)的促炎反應(yīng)。該研究首次嘗試開(kāi)發(fā)高性能光熱CO2納米催化劑，以實(shí)現(xiàn)原位CO生成，同時(shí)抑制細(xì)菌生長(zhǎng)和減輕炎癥反應(yīng)。