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雜志名稱：Advanced Materials
影響因子：27.4
文章題目：Hydrolysis of 2D Nanosheets Reverses Rheumatoid Arthritis Through Anti-Inflammation and Osteogenesis
DOI: https://doi.org/10.1002/adma.202415543
作者：Penghao Ji, Shuwen Qiu, Junchao Huang, Liping Wang, Yuemei Wang, Peng Wu, Minfeng Huo, Jianlin Shi
作者單位：上海第十人民醫(yī)院；上海納米催化醫(yī)學(xué)前沿科學(xué)中心；生物醫(yī)學(xué)工程與納米科學(xué)研究所；同濟(jì)大學(xué)醫(yī)學(xué)院；中國科學(xué)院上海硅酸鹽研究所；高性能陶瓷與超細(xì)結(jié)構(gòu)國家重點實驗室
引用YOBIBIO產(chǎn)品：U96-9403R Rabbit TNF-α ELISA kit；U96-9405R Rabbit IL-6 ELISA kit；U96-9406R Rabbit IL-10 ELISA kit
文獻(xiàn)摘要：
Rheumatoid arthritis (RA) is a kind of inflammation homeostasis disorder that dysfunctions the joints. Clinically, medications against RA focus simply on mitigating the focal inflammation, without considering pro‐osteogenesis re‐modeling of the bone microenvironment. In the present work, 2D layered calcium disilicide nanoparticles (CSNs) are fabricated by facile aqueous exfoliation. The hydrolysis of CSNs produces anti‐oxidative H2, alkaline Ca(OH)2, and silica. These moieties play significant roles in anti‐oxidation, anti‐inflammation, and pro‐osteogenesis resulting in considerably better RA therapeutic consequences than anti‐inflammation alone. Hydrogen gas is validated to eliminate excessive hydroxyl radicals and regulate macrophage re‐polarization; the generated Ca(OH)2 can neutralize the acidic microenvironment and inhibit the osteoclast activity; and, the dissolved Ca2+ can effectively complex with phosphates to mineralize Ca3(PO4)2, promoting the osteogenesis of the focal joint. The multifunctional performances of CSNs are further confirmed in arthritic mouse and rabbit models, providing an advanced and robust therapeutic strategy against RA with high biocompatibility and clinical transformable promises.
類風(fēng)濕性關(guān)節(jié)炎 （RA） 是一種使關(guān)節(jié)功能障礙的炎癥穩(wěn)態(tài)障礙。在臨床上，針對 RA 的藥物僅側(cè)重于減輕局灶性炎癥，而不考慮骨微環(huán)境的促成骨重塑。在本工作中，通過簡單的水性剝離制備了 2D 層狀二硅化鈣納米顆粒 （CSN）。CSN 的水解產(chǎn)生抗氧化 H2、堿性 Ca(OH)2 和二氧化硅。這些部分在抗氧化、抗炎和促成骨方面發(fā)揮重要作用，導(dǎo)致比單獨抗炎更好的 RA 治療效果。氫氣經(jīng)驗證可消除過量的羥基自由基并調(diào)節(jié)巨噬細(xì)胞再極化;生成的 Ca(OH)2 可以中和酸性微環(huán)境并抑制破骨細(xì)胞活性;并且，溶解的 Ca2+ 可以有效地與磷酸鹽絡(luò)合，使 Ca3(PO4)2 礦化，促進(jìn)局灶關(guān)節(jié)的成骨。CSN 的多功能性能在關(guān)節(jié)炎小鼠和兔模型中得到進(jìn)一步證實，提供了一種先進(jìn)而穩(wěn)健的 RA 治療策略，具有高生物相容性和臨床可轉(zhuǎn)化前景。