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雜志名稱：Advanced Functional Materials
影響因子：18.5
文章題目：2D Black Ferroelectric Perovskite Nanocatalysts Enable Defect Modulation-Augmented Piezocatalytic Glioma Therapy
DOI: https://doi.org/10.1002/adfm.202412983
作者：Huan Li, Chao Ma, Linqi Wang, Tong Li, Peng Li, Yu Hu, Xinyue Dai, Dejun Wu, Meiqi Chang, Yu Chen, Tao Xu
作者單位：首都醫(yī)科大學(xué)北京天壇醫(yī)院；安徽醫(yī)科大學(xué)第二附屬醫(yī)院；上海大學(xué)；上海市立中醫(yī)藥醫(yī)院上海中醫(yī)藥大學(xué)；中國海軍醫(yī)科大學(xué)長征醫(yī)院
引用YOBIBIO產(chǎn)品：U22-001A Cell Counting Kit（CCK-8）試劑盒；U21-259B PBS 緩沖液；U21-265B DMEM高糖培養(yǎng)基；U31-301C Penicillin Streptomycin（雙抗100X，青鏈霉素混合液）；U11-020A 優(yōu)級(jí)胎牛血清 Superior FBS
文獻(xiàn)摘要：
Enhancing the efficacy of glioma treatment poses a significant challenge. Ferroelectric nanomaterials, renowned for their remarkable piezoelectric properties, generate reactive oxygen species (ROS) when exposed to external stimuli or specific environmental conditions. This characteristic positions them as promising platforms for highly effective cancer therapies. In this study, two-dimensional (2D) black Bi4Ti3O12 ferroelectric perovskite nanocatalysts with engineered oxygen vacancies are designed as potent sources of ROS for efficient glioma therapy. The band bending due to ferroelectric polarization and the narrowed bandgap induced by engineered oxygen vacancy defects effectively enhance carrier separation, suppress recombination rates, and markedly increase ROS production. Moreover, mitochondrial dysfunction and activation of the mitogen-activated protein kinase (MAPK) pathways contribute to the favorable anti-tumor effects. In vitro cellular-level assessments and in vivo antineoplastic evaluations unequivocally demonstrate the enhanced cytotoxicity and effective tumor suppression enabled by this piezo-catalytic treatment strategy. This research underscores the role of defect engineering in optimizing the effectiveness of ferroelectric semiconductors for catalytically inducing apoptosis in glioma cells.
提高膠質(zhì)瘤治療的療效是一項(xiàng)重大挑戰(zhàn)。鐵電納米材料以其卓越的壓電性能而聞名，當(dāng)暴露于外部刺激或特定環(huán)境條件時(shí)，會(huì)產(chǎn)生活性氧 （ROS）。這一特性使它們成為高效癌癥治療的有前途的平臺(tái)。在這項(xiàng)研究中，具有工程氧空位的二維 （2D） 黑色 Bi4Ti3O12 鐵電鈣鈦礦納米催化劑被設(shè)計(jì)為高效神經(jīng)膠質(zhì)瘤治療的 ROS 的有效來源。鐵電極化引起的帶彎曲和工程氧空位缺陷引起的帶隙變窄，有效地增強(qiáng)了載流子分離，抑制了復(fù)合速率，并顯著增加了 ROS 的產(chǎn)生。此外，線粒體功能障礙和絲裂原活化蛋白激酶 （MAPK） 途徑的激活有助于良好的抗腫瘤作用。體外細(xì)胞水平評(píng)估和體內(nèi)抗腫瘤評(píng)估明確證明了這種壓電催化治療策略增強(qiáng)的細(xì)胞毒性和有效的腫瘤抑制。這項(xiàng)研究強(qiáng)調(diào)了缺陷工程在優(yōu)化鐵電半導(dǎo)體催化誘導(dǎo)神經(jīng)膠質(zhì)瘤細(xì)胞凋亡的有效性方面的作用。